Editorial: Tweaking T cell receptor signaling thresholds through DAG: the role of diacylglycerol kinase ζ in T cell responses to TGF-β.
نویسنده
چکیده
a unique interferon-b signaling axis mediated via the receptor IFNAR1. Nat. Immunol. 14, 901–907. 8. Brierley, M. M., Marchington, K. L., Jurisica, I., Fish, E. N. (2006) Identification of GASdependent interferon-sensitive target genes whose transcription is STAT2-dependent but ISGF3-independent. FEBS J. 273, 1569–1581. 9. Krakauer, M., Sorensen, P., Khademi, M., Olsson, T., Sellebjerg, F. (2008) Increased IL10 mRNA and IL-23 mRNA expression in multiple sclerosis: interferon-beta treatment increases IL-10 mRNA expression while reducing IL-23 mRNA expression. Mult. Scler. 14, 622–630. 10. Rudick, R. A., Ransohoff, R. M., Peppler, R., VanderBrug Medendorp, S., Lehmann, P., Alam, J. (1996) Interferon beta induces interleukin-10 expression: relevance to multiple sclerosis. Ann. Neurol. 40, 618–627.
منابع مشابه
TCR signaling intensity controls CD8+ T cell responsiveness to TGF-β.
DGK-ζ is a negative regulator of TCR signaling that causes degradation of the second messenger DAG, terminating DAG-mediated activation of Ras and PKCθ. Cytotoxic T cells deficient in DGK-ζ demonstrate enhanced effector functions in vitro and antitumor activity in vivo, perhaps because of insensitivity to inhibitory cytokines. We sought to determine whether the enhanced responsiveness of DGK-ζ-...
متن کاملDown-regulation of miR-135b in colon adenocarcinoma induced by a TGF-β receptor I kinase inhibitor (SD-208)
Objective(s):Transforming growth factor-β(TGF-β) is involved in colorectal cancer (CRC). The SD-208 acts as an anti-cancer agent in different malignancies via TGF-β signaling. This work aims to show the effect of manipulation of TGF-β signaling on some miRNAs implicated in CRC. Materials and Methods: We investigated the effects of SD-208 on SW-48, a colon adenocarcinoma cell line. The cell li...
متن کاملRegulation of Lipid Signaling by Diacylglycerol Kinases during T Cell Development and Function
Diacylglycerol (DAG) and phosphatidic acid (PA) are bioactive lipids synthesized when the T cell receptor binds to a cognate peptide-MHC complex. DAG triggers signaling by recruiting Ras guanyl-releasing protein 1, PKCθ, and other effectors, whereas PA binds to effector molecules that include mechanistic target of rapamycin, Src homology region 2 domain-containing phosphatase 1, and Raf1. While...
متن کاملTight regulation of diacylglycerol-mediated signaling is critical for proper invariant NKT cell development.
Type I NKT cells, or invariant NKT (iNKT) cells, express a semi-invariant TCR characterized by its unique Vα14-Jα18 usage (iVα14TCR). Upon interaction with glycolipid/CD1d complexes, the iVα14TCRs transduce signals that are essential for iNKT selection and maturation. However, it remains unclear how these signals are regulated and how important such regulations are during iNKT development. Diac...
متن کاملDiacylglycerol Kinases: Shaping Diacylglycerol and Phosphatidic Acid Gradients to Control Cell Polarity
Diacylglycerol kinases (DGKs) terminate diacylglycerol (DAG) signaling and promote phosphatidic acid (PA) production. Isoform specific regulation of DGKs activity and localization allows DGKs to shape the DAG and PA gradients. The capacity of DGKs to constrain the areas of DAG signaling is exemplified by their role in defining the contact interface between T cells and antigen presenting cells: ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Journal of leukocyte biology
دوره 98 5 شماره
صفحات -
تاریخ انتشار 2015